The New Rising Concern: ‘Ozempic Face’

As GLP-1 medications like Ozempic® and Wegovy® continue to surge in popularity for weight loss, many patients are noticing an unexpected effect: facial volume loss, often referred to as “Ozempic Face.”

Rapid or significant weight loss can lead to:

• Hollowing in the cheeks and temples

• More visible fine lines

• A tired or aged appearance

While GLP-1 medications themselves aren’t harmful to facial structure, the fat loss that accompanies them can accelerate these visible changes.

In fact, major semaglutide studies—like the STEP trial published in the New England Journal of Medicine—show average weight reductions of around 15%, which can contribute to noticeable changes in facial contour.

The reassuring news? These effects are purely aesthetic and highly correctable with strategic volume restoration and skin-quality treatments.

RF Microneedling

Rapid weight loss can leave skin loose, crepey, or sagging. Potenza combines microneedling with radiofrequency (RF) energy to stimulate collagen and elastin production in the dermis.

This promotes skin tightening, improved texture, and firmer contours along the jawline, cheeks, and temples. By remodeling the skin’s structural proteins, it’s particularly effective for “Ozempic Face,” especially when paired with volume-restoring treatments.

Hyaluronic acid fillers

Rapid weight loss can cause visible facial volume loss, especially in the cheeks, temples, and midface. HA fillers restore this volume by attracting and holding water in the dermis, mimicking natural tissue plumpness

They also provide structural support to overlying skin, smoothing folds and enhancing contours. When combined with treatments like Potenza RF Microneedling, HA fillers help achieve a refreshed, natural, and youthful appearance.

Biostimulator (collagen boosters) such as Exosomes, Mesotherapy with HA, Radiesse, Sculptra and Plasma

Biostimulators work by stimulating your body’s own collagen and elastin production rather than simply adding volume. Treatments like Exosomes, Sculptra, Radiesse, Plasma

and HA-based mesotherapy gradually rebuild the skin’s underlying structure, improving firmness, elasticity, and overall texture over time. Unlike fillers, their results develop naturally over several weeks, providing long-lasting rejuvenation and a subtle lift that complements other treatments such as RF microneedling or dermal fillers.

Together, these treatments not only restore lost volume but also rejuvenate skin quality from within—addressing both the structural and textural changes caused by rapid weight loss. At Papillon Bleu Aesthetics, we personalize each plan to rebalance facial proportions, enhance collagen renewal, and maintain a natural, refreshed look that reflects your healthy transformation rather than the side effects of it.

PF Microneedling